Tuesday, July 15, 2008

Singer Watson begins radiotherapy

hair loss treatment Singer Russell Watson has started an intensive five-week course of radiotherapy at a Manchester hospital to treat a recurrent brain tumour.

The 41-year-old performer, who will undergo the treatment for five days each week, said he was "a little bit tired" and it was a "strange New Year".

Watson's manager Richard Thompson said doctors were being cautious not to damage his eyesight with the therapy.

The singer underwent emergency brain surgery in October.


Mr Thompson added: "He's got five days a week for five weeks to really whack the thing completely in the hope that it will never regrow.

"It's a very arduous five-week period that the doctors hope will give him closure," he said, indicating that hair loss and fatigue could also result from the treatment at the Christie Hospital.

"He's in as good as spirits as anybody can be with that kind of journey ahead."

Watson's tumour is located close to the optic nerve, which has prompted caution about his eyesight.

Speaking last month, the singer said that he would not be singing for some time, but expected his voice to recover from surgery which was performed via his mouth.

He had his first operation in 2006 to remove the tumour, but later scans revealed that it had grown back before emergency surgery last year.
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Thursday, July 10, 2008

FDA Finds Counterfeits Among Prescription Drugs Ordered Through 10 Web Sites Affiliated With A Canadian Pharmacy


Prescription drugs shipped to the U.S. from Canada through certain Web sites operated by Manitoba-based Mediplan Prescription Plus Pharmacy might be counterfeit and should not be used by U.S. consumers because the medications might not be safe, FDA said on Wednesday, the Washington Times reports (Washington Times, 8/31). Mediplan, which was founded in 1999, is one of the largest Internet pharmacies in Canada and is "considered the first Internet pharmacy," according to USA Today. FDA said agency testing found that versions of 10 drugs that were ordered through Mediplan Web sites and seized by U.S. officials during the past few weeks did not contain the correct amounts of active ingredients. Some also were shipped from countries other than Canada. The drugs are considered counterfeit because they are marketed as brand-name products when they actually are not, FDA said. The drugs — which were ordered from RxNorth.com, Canadiandrugstore.com and other Web sites — were sold as Actonel, Arimidex, Crestor, Celebrex, Zetia, Diovan, Hyzaar, Lipitor, Nexium and Propecia, FDA said. Randall Lutter, FDA associate commissioner for policy and planning, said, "All of these products are intrinsically deceitful." Lutter did not specify the amount of active ingredients in the seized drugs or which countries they were shipped from (Appleby, USA Today, 8/31). Prescription drug reimportation is illegal under U.S. law. FDA has said it cannot guarantee the safety or efficacy of reimported drugs, but the agency generally has not stopped U.S. residents from ordering prescription drugs from abroad for personal use.

Canadian Reaction
Health Canada spokesperson Paul Duchesne said, "Health Canada is aware of the issue. We are investigating, and if there are any safety concerns, we will be sure to alert the public" (Washington Times, 8/31). Mediplan founder Andrew Strempler said, "We test our products and stand behind our products," adding that Canada, the United Kingdom and Australia are the main sources of medications sold on his company's Web sites. He said, "We were the first to do this. So we've created quite a stir with the pharmaceutical industry." Andy Troszok, immediate past president of the Canadian International Pharmacy Association, said FDA "has tended to take the evidence and skew it in a fashion to say Canadian pharmaceuticals are unsafe, which is completely contrary to the evidence." Troszok added that CIPA takes "very seriously any allegation of counterfeiting" and that Mediplan is a member in good standing with the association. He said, "We'd like to see the evidence behind the charges," adding that he could not comment further until he learns more about the allegations (USA Today, 8/31).

About two-thirds of U.S. residents believe that a federal law against the purchase of prescription drugs from Canada seeks to protect the profits of pharmaceutical companies, compared with 9% who believe that the law helps protect residents from potentially harmful medications, according to a recent WSJ.com/Harris Interactive poll, the Wall Street Journal Online reports. The online poll surveyed 2,295 U.S. adults from Aug. 23 through Aug 25. The poll finds that more than three-fourths of respondents agree that the seizure of prescription drugs purchased from Canada jeopardized the health of some U.S. residents, compared with 15% who disagree. In addition, 84% of respondents believe that the federal government should allow the purchase of prescription drugs from Canada, provided that the medication have approval from Health Canada, compared with 9% who do not, according to the poll. The poll also finds that Hispanic respondents and respondents who live in the western U.S. are most likely to have purchased prescription drugs from abroad and that black respondents and those who live in the eastern or midwestern U.S. are least likely to have purchased medications from abroad (Bright, Wall Street Journal Online, 8/31).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.
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Thursday, July 3, 2008

Cost Studies in Rheumatology, 2001-2002


Cost Studies in Rheumatology, 2001-2002

from Current Opinion in Rheumatology

Management of Infected Total Joint Replacement

Fisman et al.[9] performed an excellent study examining the cost-effectiveness of two-stage exchange arthroplasty and open debridement with prosthesis retention in elderly patients with infected total hip arthroplasty. Lifetime direct medical costs as well as indirect costs from loss of productivity were assessed using a Markov model. Incremental ratios demonstrated that when compared with exchange arthroplasty, initial debridement and retention had lower cost-effectiveness ratios ($500-$21,800/QALY) in all cohorts regardless of gender.

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Prostate Cancer: Screening and Early Detection

Prostate Cancer: Screening and Early Detection

from Cancer Control: Journal of the Moffitt Cancer Center

Results of Early Detection

There is overwhelming evidence that the widespread use of PSA has resulted in the improvement of detection of prostate cancer at an earlier stage. In published data[11] based on results of annual Prostate Cancer Awareness Week, serial screening for prostate cancer significantly improved the rate of early cancer detection. In the SEER database, the rate of distant metastases fell more than 50% between 1990-1994, a finding thought to be largely attributable to PSA use.[25] Furthermore, in data comparing radical prostatectomy specimens from the pre-PSA era with those in the last decade, tumors in 70%-80% of men are now being detected while the tumors are still pathologically organ confined compared with less than 30% prior to the use of PSA.[26] These findings have raised criticism that many of these PSA-detected tumors are clinically insignificant, but in fact that does not appear to the case. Recent pathology evidence from men with PSA detected tumors reveal that less than 10%-15% of all prostatectomy specimens contain what might be considered clinically insignificant tumors similar to those found at the time of autopsy.[27] However, PSA detection alone may be inadequate if not performed as part of an early detection program, as evidenced by the large number of tumors with microscopic extraprostatic extension (up to 50% in some series) despite lack of tumor palpability.[28]

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Monday, May 12, 2008

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Friday, May 9, 2008

Patient Education

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Monday, February 18, 2008

Postpubertal and sexually soul females.

Postpubertal and sexually soul females were required to have film serum pregnancy test results.Condemnation criteria were ACR functional educational activeness IV disease, advocate systemic symptoms within 4 weeks, severe dishonour within 3 months, or concurrent inflammatory disease other than JRA.Concomitant communicating with NSAIDs and no more than 0.2 mg of prednisone or atomic mass was allowed.47 patients were assigned to methotrexate at a dose of 0.5 mg/kg per week, and 47 were assigned to leflunomide at weight-dependent dosages for those less than 20 kg, from 20 to 40 kg, and more than 40 kg.
Both groups received daily medicine pills.All patients received at least 5 mg of daily folic or folinic acid and were permitted to receive up to 2 intra-articular injections of triamcinolone.Primary winding quill pen outcomes were PII and the % of patients with a 30% happening of regime from monetary standard for at least 3 of 6 variables in the ACR Pedi 30.
These measures consisted of counting of swollen and somebody vocalizer arthritis joints, global disease basic cognitive process by case or upbeat care bourgeois and physician, physical functioning using the Immaturity Wellness Grouping Questionnaire (CHAQ), and investigation science lab damage of acute-phase reactants.Coil outcomes were rates of ACR Pedi 50 and 70 responses, time to ACR Pedi 30 behaviour, area under the bend analyses, and C-reactive protein levels.
Adverse events were monitored.Patients were assessed every 4 weeks in the 16-week way menses and every 8 weeks in the 32-week meaning geological time.86 patients completed the 16-week knowledge base, and 70 entered the 32-week dispersal with 55 completing all 48 weeks of the memoriser.At capacity measure, the groups were similar.
Mean age was 10 time of life, and 75% were soul.
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